Antiepileptic Drugs: Quantitative Analysis and Interpretation

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Antiepileptic Drugs

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Antiepileptic Drugs

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Antiepileptic drugs and suicidality

The risk of suicide in patients with epilepsy is significantly higher than the general population. There are many hypotheses as to the reasons for this, but the potential role of anti-epileptic drugs (AEDs) in increasing suicidality has recently been brought into question. In 2008, the U.S. Food and Drug Administration (FDA) published a warning after a meta-analysis of data from all clinical tr...

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Antiepileptic drugs and suicidality.

The current study is a systematic review of the literature concerning the possible relationship of antiepileptics and suicide-related clinical features and behaviours. A MEDLINE search returned 863 papers but only five were chosen as relevant. A critical analysis of the Food and Drug Administration report is also included. Overall, the current review suggests there are no convincing data concer...

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In a recent CMAJ commentary on drug interactions with warfarin, David Juurlink overlooked a very important category of drugs that interact with warfarin: antiepileptic drugs. Phenytoin, carbamazepine and phenobarbital are potent inducers of the cytochrome P450 system, and their interactions with warfarin have been known for decades. These drugs can substantially increase the rate at which warfa...

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ژورنال

عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry

سال: 1979

ISSN: 0022-3050

DOI: 10.1136/jnnp.42.5.482-c